[Todos] charla sobre plasticidad sinaptica

[Alejandro Delorenzi]

Hoy Miércoles 26/05/04 , C12 hs charla sobre plasticidad sinaptica en el:

Laboratorio de Neurobiologia de la Memoria,
Departamento de Fisiología y Biologia Molecular,
Pabellon II, FCEyN


El rol del gen inmediato temprano arc en la transmisión sináptica



Emiliano Rial Verde

Post doc Cold Spring Harbour Labs (USA)

Vie


ARC (activity-regulated cytoskeleton-associated gene) is an immediate-early 
gene induced by synapse-strengthening activity patterns. ARC mRNA is 
transported specifically to activated dendritic regions where the protein 
is locally translated. Such properties make ARC a good candidate to link 
activity-dependent transcriptional response with long-lasting 
synapse-specific plastic changes. This thesis investigates the effect of 
increased levels of ARC protein on synaptic transmission. Surprisingly, ARC 
induces depression of synaptic currents mediated by AMPA-type glutamate 
receptors (AMPARs). This ARC-induced depression targets a specific subtype 
of AMPARs. Such specificity offers a mechanism for differential regulation 
of synaptic strength depending on the AMPAR subtype composition at the 
synapse. My data support a model for ARC action in plasticity whereby ARC 
serves the dual purpose of increasing the local signal-to-noise ratio of 
excitatory inputs onto pyramidal cell dendrites, while homeostatically 
regulating total synaptic strength.
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