[Lcefiec] Invitación a Seminario

Fri, 14 Nov 2003 14:08:29 -0300

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Viernes 5 de Diciembre 
IIB-FCEyN- Fundación Instituto Leloir
Av. Patricias Argentinas 435

14 hs: Joan Steitz-  Department of Molecular Biophysics and Biochemistry,
Yale University Medical School, Howard Hughes Medical Institute, USA.
"Pre-mRNA Splicing:  Impacting Downstream Events in Gene Expression"

15:30 hs: Lynne Maquat-Department of Biochemistry and Biophysics, School of
Medicine and Dentistry, University of Rochester, USA.
"Nonsense-mediated mRNA decay in mammalian cells: Splicing-dependent 
degradation that occurs 5'-to-3' and 3'-to-5' after a pioneer round of 
translation"

Gallouzi IE, Brennan CM, Steitz JA. 2003. Protein ligands mediate the
CRM1-dependent export of HuR in response to heat shock. Rna 9: 1410
Hirose T, Shu MD, Steitz JA. 2003. Splicing-dependent and -independent modes
of assembly for intron-encoded box C/D snoRNPs in mammalian cells. Mol Cell
12: 113-23
Huang Y, Gattoni R, Stevenin J, Steitz JA. 2003. SR splicing factors serve
as adapter proteins for TAP-dependent mRNA export. Mol Cell 11: 837-43
Otake LR, Scamborova P, Hashimoto C, Steitz JA. 2002. The divergent U12-type
spliceosome is required for pre-mRNA splicing and is essential for
development in Drosophila. Mol Cell 9: 439-46
Gallouzi IE, Steitz JA. 2001. Delineation of mRNA export pathways by the use
of cell-permeable peptides. Science 294: 1895-901
Lykke-Andersen J, Shu MD, Steitz JA. 2001. Communication of the position of
exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.
Science 293: 1836-9
Huang Y, Steitz JA. 2001. Splicing factors SRp20 and 9G8 promote the
nucleocytoplasmic export of mRNA. Mol Cell 7: 899-905
Voeltz GK, Ongkasuwan J, Standart N, Steitz JA. 2001. A novel embryonic
poly(A) binding protein, ePAB, regulates mRNA deadenylation in Xenopus egg
extracts. Genes Dev 15: 774-88
Lykke-Andersen J, Shu MD, Steitz JA. 2000. Human Upf proteins target an mRNA
for nonsense-mediated decay when bound downstream of a termination codon.
Cell 103: 1121-31

Lejeune F, Li X, Maquat LE. 2003. Nonsense-mediated mRNA decay in mammalian
cells involves decapping, deadenylating, and exonucleolytic activities. Mol
Cell 12: 675-87
Lejeune F, Ishigaki Y, Li X, Maquat LE. 2002. The exon junction complex is
detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells:
dynamics of mRNP remodeling. Embo J 21: 3536-45
Maquat LE. 2002. Molecular biology. Skiing toward nonstop mRNA decay.
Science 295: 2221-2
Maquat LE. 2002. NASty effects on fibrillin pre-mRNA splicing: another case
of ESE does it, but proposals for translation-dependent splice site choice
live on. Genes Dev 16: 1743-53
Ishigaki Y, Li X, Serin G, Maquat LE. 2001. Evidence for a pioneer round of
mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian
cells are bound by CBP80 and CBP20. Cell 106: 607-17
Maquat LE, Carmichael GG. 2001. Quality control of mRNA function. Cell 104:
173-6
Le Hir H, Moore MJ, Maquat LE. 2000. Pre-mRNA splicing alters mRNP
composition: evidence for stable association of proteins at exon-exon
junctions. Genes Dev 14: 1098-108

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Graciela. L. Boccaccio Ph. D.
Myelin Biology Laboratory
Fundación Instituto Leloir (formerly IIB Fundación Campomar)
IIB-University of Buenos Aires
IIBBA-CONICET
Av. Patricias Argentinas 435
1405 Buenos Aires - Argentina

e-mail: gboccaccio@leloir.org.ar <mailto:gboccaccio@leloir.org.ar> 
TEL: 54 11 4863-4011 to 4019
FAX: 54 11 4865-2246
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